Saint Anne, the Virgin, Saint Elisabeth, Saint John and the Child Jesus

Fernando Yáñez de la Almedina painted this Saint Anne, the Virgin, Saint Elizabeth, Saint John, and the Christ Child around 1510, a complex sacred kinship composition bringing together the extended family of Christ in a devotional assembly. The sacred kinship—Anna, Mary, Elizabeth, and the holy children—was a particularly important devotional type in Valencian painting, the extended family group providing a richer emotional and intercessory context than the more nuclear Holy Family compositions. Yáñez had worked in Leonardo's Milanese workshop around 1505–1506, and his figure types reflect this formation: the Leonardesque sfumato, the carefully observed children's physiognomies, and the psychological intimacy of the family grouping all bear witness to his direct exposure to Leonardo's revolutionary approach to sacred painting.

The multi-generational Holy Family composition shows Yáñez's absorption of Italian Renaissance principles, particularly Leonardo's soft sfumato modeling and pyramidal figure arrangements. The work bridges Spanish devotional tradition with Italian High Renaissance forms.