Virgin and Child with Saint Jerome, Saint Anthony of Padua and Two Angels

Francesco di Giorgio's Virgin and Child with Saints Jerome, Anthony of Padua, and Others belongs to the Sienese master's production of devotional altarpieces alongside his better-known architectural and engineering achievements. Francesco di Giorgio was one of the most universal geniuses of the Italian Renaissance, practicing simultaneously as painter, sculptor, architect, and military engineer. His paintings, less studied than his architecture, demonstrate his thorough grounding in Florentine figurative tradition combined with the Sienese sweetness of his native city's aesthetic heritage.

The composition balances the traditional Sienese emphasis on elegant line and luminous color with a more developed sense of spatial depth that reflects Francesco di Giorgio's concurrent interest in architectural perspective.