The Virgin Cardiotissa (Kardiotissa).

Angelos Akotantos created this work around 1450, now in the Byzantine and Christian Museum. The depiction of the Virgin and Child was the single most common subject in Italian Renaissance art, serving as a focus for both private devotion and public worship. The Early Renaissance period saw significant artistic innovation across Europe, with painters developing new techniques for representing the visible world with unprecedented naturalism and spatial coherence.

The Madonna's pose and the Christ Child's gestures follow codified devotional types, with the artist investing these conventional forms with individual character through subtle variations in expression and color.